Description
α-Conotoxin ACV 1, also known as α-conotoxin Vc1.1, is a synthetic version of a 16-amino acid conopeptide initially derived from the venom of marine cone snails, specifically the Conus victoriae species. This peptide exhibits the characteristic three-dimensional structure of α-conotoxins, featuring a helical region stabilized by two disulfide bonds. α-Conotoxin ACV 1 belongs to the α-conotoxin family, known for their ability to selectively target and modulate nicotinic acetylcholine receptors (nAChRs) in the nervous system, specifically the α9α10 subtype. In recent years, α-conotoxin ACV 1 has garnered significant scientific interest due to its therapeutic potential, particularly in the treatment of chronic neuropathic pain. It has demonstrated efficacy in alleviating certain neuropathic pains and promotes the accelerated recovery of injured neurons. α-Conotoxin ACV 1 also acts on human dorsal root ganglion (DRG) neurons by activating the GABAB receptor, a key player in the initial stages of pain processing. This dual mechanism highlights its potential as a promising therapeutic agent for managing neuropathic pain.
Specification
| Item | α-Conotoxin ACV 1 |
|---|
| Catalog | MC740980249 |
| CAS | 740980-24-9 |
| Molecular Formula | C71H103N23O25S4 |
| Molecular Weight | 1806.98 |
| Purity | >98% |
| Sequence | Gly-Cys-Cys-Ser-Asp-Pro-Arg-Cys-Asn-Tyr-Asp-His-Pro-Glu-Ile-Cys-NH2 (Disulfide bridge: Cys2-Cys8, Cys3-Cys16) |
| Sequence Shortening | GCCSDPRCNYDHPEIC-NH2 (Disulfide bridge: Cys2-Cys8, Cys3-Cys16) |
| Length (AA) | 16 |
| Density | 1.31 g/cm3 |
| InChI Key | KJQOYUHYAZGPIZ-PIJHVLQJSA-N |
| Peptide Content | 100% |
| Form | Lyophilized powder |
| Source | Synthetic peptide |
| Storage | Product as supplied should be stored at -20 °C. Protect from moisture. |
| Solubility | Soluble in water |
| Storage of Solutions | Store up to one week at 4 °C or up to 6 months at -20 °C. |
Choose Alfa Chemistry
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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
