Description
α-Conotoxin Bt1.8, a peptide toxin composed of 16 amino acids, is originally derived from the venom duct of the worm-hunting cone snail, Conus betulinus. The unique structure of α-conotoxin Bt1.8, characterized by its compact size and disulfide bonds, contributes to its specificity and affinity for binding to target receptors. This toxin is classified under the α4/7-conotoxin subfamily, which primarily targets vertebrate neuronal nicotinic acetylcholine receptors (nAChRs). It exhibits high potency and selectivity in blocking neuronal nAChRs, specifically targeting the α6/α3β2β3 and α3β2 subtypes. The inhibitory concentration (IC50) values for these interactions are 2.1 nM and 9.4 nM, respectively. The specific interaction of α-conotoxin Bt1.8 with these receptors provides valuable insights into their structure and function, making it a significant tool in neuropharmacology and biochemistry. As its intricate mechanisms continue to be deciphered, α-conotoxin Bt1.8 presents potential applications in drug development for neurological disorders, pain management, and even as a bioactive probe in neuroscientific research.
Specification
| Item | α-Conotoxin Bt1.8 |
|---|
| Catalog | MC045 |
| Molecular Formula | C63H100N22O22S4 |
| Molecular Weight | 1645.86 |
| Purity | >98% |
| Sequence | Gly-Cys-Cys-Ser-Asn-Pro-Ala-Cys-Ile-Leu-Asn-Asn-Pro-Asn-Gln-Cys-NH2 (Disulfide bridge: Cys2-Cys8, Cys3-Cys16) |
| Sequence Shortening | GCCSNPACILNNPNQC-NH2 (Disulfide bridge: Cys2-Cys8, Cys3-Cys16) |
| Length (AA) | 16 |
| Peptide Content | 100% |
| Form | Lyophilized powder |
| Source | Synthetic peptide |
| Storage | Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20 °C. Protect from light and moisture. |
| Solubility | Soluble in water |
| Storage of Solutions | Store up to one week at 4 °C or up to 6 months at -20 °C. |
Choose Alfa Chemistry
Alfa Chemistry is dedicated to maintaining exceptional quality and a relentless focus on innovation. We aim to unlock the vast potential of marine resources by offering a diverse array of high-quality products. We are pleased to provide you with top-grade α-conotoxin Bt1.8 at a competitive price. If you have any inquiries or specific requirements, please do not hesitate to contact us.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
