Description
α-Conotoxin GI is a peptide derived from the venom of the marine cone snail species Conus geographus, consisting of 13 amino acids and 2 disulfide bonds. This neurotoxic compound is a member of the conotoxin A superfamily, which consists of diverse small peptides that target various ion channels and receptors in the nervous system. α-Conotoxin GI acts as a competitive antagonist of muscle-type nicotinic acetylcholine receptors (AChR). It can distinguish between two agonist sites, as it generally binds to the α/δ site with much higher selectivity than the α/γ site. The unique structure and mechanism of action of α-conotoxin GI provide insights into synaptic transmission and have potential implications for the development of novel therapeutics for neurological disorders.
Specification
| Item | α-Conotoxin GI |
|---|
| Catalog | MC76862652 |
| CAS | 76862-65-2 |
| Molecular Formula | C55H80N20O18S4 |
| Molecular Weight | 1437.61 |
| Purity | >97% |
| Sequence | Glu-Cys-Cys-Asn-Pro-Ala-Cys-Gly-Arg-His-Tyr-Ser-Cys-NH2 (Disulfide bridge: Cys2-Cys7, Cys3-Cys13) |
| Sequence Shortening | ECCNPACGRHYSC-NH2 (Disulfide bridge: Cys2-Cys7, Cys3-Cys13) |
| Length (AA) | 13 |
| Peptide Content | 100% |
| Form | White lyophilized solid |
| Source | Synthetic peptide |
| Storage | Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20 °C. |
| Solubility | Water or saline buffer |
| Storage of Solutions | Up to two weeks at 4 °C or three months at -20 °C. |
Therapeutic Potential
Due to its selectivity and efficacy in blocking specific subtypes of nicotinic AChRs, α-conotoxin GI is being investigated for its potential in treating conditions such as:
- Chronic pain
- Neuromuscular disorders
- Cognitive enhancement and memory-related disorders
Choose Alfa Chemistry
Alfa Chemistry is dedicated to maintaining exceptional quality and a relentless focus on innovation. We aim to unlock the vast potential of marine resources by offering a diverse array of high-quality products. We are pleased to provide you with top-grade α-conotoxin GI at a competitive price. If you have any inquiries or specific requirements, please do not hesitate to contact us.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
