Description
α-Conotoxin ImI, derived from the venom of the marine cone snail Conus imperialis, stands out as the first and only small-peptide ligand that selectively binds to the neuronal α7 homopentameric subtype of the nicotinic acetylcholine receptors (nAChRs). This particular receptor subtype is considered a promising drug target for various neurological disorders. It also blocks the homologous α9 receptors with an apparent affinity 8-fold lower than that of the α7 receptor. However, it has no effect on nAChRs composed of α2/β2, α3/β2, α4/β2, α2/β4, α3/β4, or α4/β4 subunits. Notably, in the structure of α-conotoxin ImI, cysteine residues are paired as Cys2-Cys8 and Cys3-Cys12, forming distinct disulfide bonds. And it is the only known α-conotoxin characterized by a 4/3 residue spacing between its cysteine pairs, highlighting its unique structural properties and potential therapeutic significance. The unique structure and properties of α-conotoxin ImI make it a subject of extensive research in pharmacology and drug development, highlighting the intriguing potential of marine biodiversity in unveiling novel therapeutic agents.
Specification
| Item | α-Conotoxin ImI |
|---|
| Catalog | MC156467855 |
| CAS | 156467-85-5 |
| Molecular Formula | C52H78N20O15S4 |
| Molecular Weight | 1351.56 |
| Purity | >95% |
| Sequence | Gly-Cys-Cys-Ser-Asp-Pro-Arg-Cys-Ala-Trp-Arg-Cys-NH2 (Disulfide bridge: Cys2-Cys8, Cys3-Cys12) |
| Sequence Shortening | GCCSDPRCAWRC-NH2 (Disulfide bridge: Cys2-Cys8, Cys3-Cys12) |
| Length (AA) | 12 |
| Peptide Content | 100% |
| Form | White lyophilized solid |
| Source | Synthetic peptide |
| Storage | Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20 °C. |
| Solubility | Water or saline buffer |
| Storage of Solutions | Up to two weeks at 4 °C or three months at -20 °C. |
Choose Alfa Chemistry
Alfa Chemistry is dedicated to maintaining exceptional quality and a relentless focus on innovation. We aim to unlock the vast potential of marine resources by offering a diverse array of high-quality products. We are pleased to provide you with top-grade α-conotoxin ImI at a competitive price. If you have any inquiries or specific requirements, please do not hesitate to contact us.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
