Description
α-Conotoxin MrIC is a 17-amino-acid peptide found in the venom duct of Conus marmoreus. It belongs to the 4/7 α-conotoxin family and is notable for its selective targeting of the α7 nicotinic acetylcholine receptor (nAChR). What sets α-conotoxin MrIC apart is its role as a biased agonist; it uniquely activates the α7 nAChR only when the receptor is influenced by type II positive allosteric modulators. This distinct characteristic makes α-conotoxin MrIC an invaluable tool for exploring the pharmacological characteristics of α7 nAChR, a key ion channel involved in neurological functions. Consequently, researchers can utilize α-conotoxin MrIC to advance the study of neurological disorders and better understand the pharmacodynamics of α7 nAChR.
Specification
| Item | α-Conotoxin MrIC |
|---|
| Catalog | MC1417816411 |
| CAS | 1417816-41-1 |
| Molecular Formula | C74H111N23O24S4 |
| Molecular Weight | 1835.07 |
| Purity | >98% |
| Sequence | Pro-Glu-Cys-Cys-Thr-His-Pro-Ala-Cys-His-Val-Ser-Asn-Pro-Glu-Leu-Cys-NH2 (Disulfide bridge: Cys3-Cys9, Cys4-Cys17) |
| Sequence Shortening | PECCTHPACHVSNPELC-NH2 (Disulfide bridge: Cys3-Cys9, Cys4-Cys17) |
| Length (AA) | 17 |
| Peptide Content | 100% |
| Form | Lyophilized powder |
| Source | Synthetic peptide |
| Storage | Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20 °C. |
| Solubility | Any aqueous buffer |
| Storage of Solutions | Up to two weeks at 4 °C or three months at -20 °C. |
Research and Applications
Due to its ability to selectively inhibit nAChR activity, α-conotoxin MrIC is of interest in biomedical research, potentially offering insights into treatments for conditions involving dysfunctional cholinergic signaling, such as pain, epilepsy, and certain neuromuscular disorders. α-Conotoxin MrIC also facilitates pharmacological studies, allowing researchers to dissect the roles of these nAChRs in various tissues.
Choose Alfa Chemistry
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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
