Description
α-Conotoxin PnIA is a small peptide toxin comprised of 16 amino acids and two pairs of disulfide bonds, isolated from the venom of the molluscivourous cone snail species Conus pennaceus. This naturally occurring compound is a potent and selective antagonist of nicotinic acetylcholine receptors (nAChRs), specifically targeting the α7 subtypes. The unique structure of α-conotoxin PnIA allows it to bind selectively to these receptors, thereby blocking the transmission of nerve impulses. Due to its specificity and effectiveness, α-conotoxin PnIA has become a valuable tool in neuroscience research, where it provides insights into the functioning and modulation of nAChRs. The study of α-conotoxin PnIA and its unique mechanisms of action also provides insight into the development of novel pharmacological agents that could modulate receptor activity in a controlled and specific way. Furthermore, its potential therapeutic applications are being explored for conditions related to dysfunctional cholinergic signaling, including neuropathic pain, Alzheimer's disease, and other neurological disorders.
Specification
| Item | α-Conotoxin PnIA |
|---|
| Catalog | MC705300841 |
| CAS | 705300-84-1 |
| Molecular Formula | C65H95N19O22S4 |
| Molecular Weight | 1622.80 |
| Purity | >95% |
| Sequence | Gly-Cys-Cys-Ser-Leu-Pro-Pro-Cys-Ala-Ala-Asn-Asn-Pro-Asp-Tyr-Cys-NH2 (Disulfide bridge: Cys2-Cys8, Cys3-Cys16) |
| Sequence Shortening | GCCSLPPCAANNPDYC-NH2 (Disulfide bridge: Cys2-Cys8, Cys3-Cys16) |
| Length (AA) | 16 |
| InChI Key | VUVGEYBNLLGGBG-MVPSLEAZSA-N |
| Form | Lyophilized powder |
| Source | Synthetic peptide |
| Storage | Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20 °C. |
| Solubility | Soluble to 5 mg/ml in water |
| Storage of Solutions | Up to two weeks at 4 °C or three months at -20 °C. |
Choose Alfa Chemistry
Alfa Chemistry is dedicated to maintaining exceptional quality and a relentless focus on innovation. We aim to unlock the vast potential of marine resources by offering a diverse array of high-quality products. We are pleased to provide you with top-grade α-conotoxin PnIA at a competitive price. If you have any inquiries or specific requirements, please do not hesitate to contact us.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
