Description
The 13-residue peptide α-conotoxin RgIA, a member of the α-4,3 family of α-conotoxins derived from the venom of Conus regius, is known for its selective inhibition of the α9α10 nicotinic acetylcholine receptor (nAChR) subtype. This receptor subtype is crucial in facilitating synaptic transmission from the medial olivocochlear complex to cochlear hair cells and has been associated with various pathological conditions, including neuropathic pain, tumor growth, and immune-mediated disorders. Given the high affinity of α-conotoxin RgIA for this receptor subtype, its discovery has made it possible to investigate the role of α9α10 nAChR in a variety of diseases.
Specification
| Item | α-Conotoxin RgIA |
|---|
| Catalog | MC876728233 |
| CAS | 876728-23-3 |
| Molecular Formula | C59H95N25O18S4 |
| Molecular Weight | 1570.80 |
| Purity | >98% |
| Sequence | Gly-Cys-Cys-Ser-Asp-Pro-Arg-Cys-Arg-Tyr-Arg-Cys-Arg (Disulfide bridge: Cys2-Cys8, Cys3-Cys12) |
| Sequence Shortening | GCCSDPRCRYRCR (Disulfide bridge: Cys2-Cys8, Cys3-Cys12) |
| Length (AA) | 13 |
| Peptide Content | 100% |
| Color | White to off-white |
| Form | Lyophilized powder |
| Source | Synthetic peptide |
| Storage | Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20 °C. |
| Solubility | Any aqueous buffer |
| Storage of Solutions | Store at 4 °C for up to 1 week. |
Therapeutic Potential
- Analgesic and anti-inflammatory effects. α-Conotoxin RgIA is a selective antagonist of α9α10 nAChRs and has been shown to be a potent analgesic that promotes nerve repair and relieves pain, and also reduces inflammation associated with nerve damage.
- Anti-colitis effects. α-Conotoxin RgIA's modulation of acetylcholine receptors can also influence gut health. In models of colitis, it is suspected to contribute to alleviating symptoms by reducing inflammation in the gut lining. This is due to its ability to decrease the production of pro-inflammatory cytokines involved in intestinal inflammation.
- Anti-cancer effects. The anti-cancer effects of α-conotoxin RgIA are less established compared to its analgesic and anti-inflammatory properties. However, some studies suggest that by modulating nAChRs, α-conotoxins may influence cancer cell proliferation and survival.
Choose Alfa Chemistry
Alfa Chemistry is dedicated to maintaining exceptional quality and a relentless focus on innovation. We aim to unlock the vast potential of marine resources by offering a diverse array of high-quality products. We are pleased to provide you with top-grade α-conotoxin RgIA at a competitive price. If you have any inquiries or specific requirements, please do not hesitate to contact us.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
