Description
α-Conotoxin SI is a bioactive peptide derived from the venom of the cone snail species Conus striatus. It consists of a small peptide chain and typically features two disulfide bonds essential for its stability and biological function. This conotoxin belongs to a diverse family of conopeptides that are characterized by their specificity and potency in targeting nicotinic acetylcholine receptors (AChRs), which play critical roles in neuromuscular transmission and synaptic communication. α-Conotoxin SI is a potent and selective antagonist of α1/β1/δ/γ nicotinic AChRs. It can be used in the study of neurological disorders.
Specification
| Item | α-Conotoxin SI |
|---|
| Catalog | MC115797063 |
| CAS | 115797-06-3 |
| Molecular Formula | C55H88N16O16S4 |
| Molecular Weight | 1357.64 |
| Purity | >98% |
| Sequence | Ile-Cys-Cys-Asn-Pro-Ala-Cys-Gly-Pro-Lys-Tyr-Ser-Cys-NH2 (Disulfide bridge: Cys2-Cys7, Cys3-Cys13) |
| Sequence Shortening | ICCNPACGPKYSC-NH2 (Disulfide bridge: Cys2-Cys7, Cys3-Cys13) |
| Length (AA) | 13 |
| Peptide Content | 100% |
| Form | Lyophilized powder |
| Source | Synthetic peptide |
| Storage | Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20 °C. |
| Solubility | Any aqueous buffer |
| Storage of Solutions | Up to two weeks at 4 °C or three months at -20 °C. |
Biological Activity
- Target specificity. Different α-conotoxins can have varying specificity for different subtypes of nicotinic AChRs. Therefore, α-conotoxin SI is a useful tool in pharmacological studies to understand receptor function.
- Pharmacological potential. Due to the precise and effective manner of modulating neurotransmission, α-conotoxin SI is of interest for potential therapeutic applications. It could serve as templates for developing drugs aimed at conditions involving dysfunctional neuromuscular communication, such as myasthenia gravis or certain types of chronic pain.
Choose Alfa Chemistry
Alfa Chemistry is dedicated to maintaining exceptional quality and a relentless focus on innovation. We aim to unlock the vast potential of marine resources by offering a diverse array of high-quality products. We are pleased to provide you with top-grade α-conotoxin SI at a competitive price. If you have any inquiries or specific requirements, please do not hesitate to contact us.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
