Description
α-Conotoxin TxID is a 15-amino-acid peptide toxin derived from Conus textile. As part of the α-4/6 conotoxin subfamily, α-conotoxin TxID demonstrates potent and highly selective antagonistic properties against the α3β4 subtype of nicotinic acetylcholine receptors (nAChRs). It also inhibits the closely related α6/α3β4 nAChR subtype, while exhibiting minimal activity towards other nAChR subtypes, setting it apart with a unique selectivity profile. This specificity makes it an invaluable tool in exploring the unique structure and functions of α3β4 nAChRs in both normal physiological and pathological conditions. Furthermore, as one of the most effective α3β4 nAChR antagonists currently known, α-conotoxin TxID emerges as a potential frontrunner in the development of treatments targeting many neurological disorders.
Specification
| Item | α-Conotoxin TxID |
|---|
| Catalog | MC1496617641 |
| CAS | 1496617-64-1 |
| Molecular Formula | C58H92N18O18S5 |
| Molecular Weight | 1489.79 |
| Purity | >98% |
| Sequence | Gly-Cys-Cys-Ser-His-Pro-Val-Cys-Ser-Ala-Met-Ser-Pro-Ile-Cys-NH2 (Disulfide bridge: Cys2-Cys8, Cys3-Cys15) |
| Sequence Shortening | GCCSHPVCSAMSPIC-NH2 (Disulfide bridge: Cys2-Cys8, Cys3-Cys15) |
| Length (AA) | 15 |
| Form | Lyophilized powder |
| Source | Synthetic peptide |
| Storage | Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20 °C. |
| Solubility | Soluble in water |
| Storage of Solutions | Store at 4 °C for up to 1 week. |
Research and Applications
- Neuroscience research. α-Conotoxins TxID is a valuable tool for understanding the roles of different subtypes of nAChRs in the nervous system. It helps dissect the physiological and pathological roles of these receptors.
- Drug development. Due to its selectivity, α-conotoxin TxID is explored for its potential as a lead compound or model for developing new drugs, particularly in pain management or treating neurological disorders.
- Biochemical tool. α-Conotoxins TxID serves as a biochemical tool to investigate receptor subtypes composition and function, aiding in the broader understanding of neurobiology.
Choose Alfa Chemistry
Alfa Chemistry is dedicated to maintaining exceptional quality and a relentless focus on innovation. We aim to unlock the vast potential of marine resources by offering a diverse array of high-quality products. We are pleased to provide you with top-grade α-conotoxin TxID at a competitive price. If you have any inquiries or specific requirements, please do not hesitate to contact us.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
