Description
αO-Conotoxin GeXIVA is a 28-amino acid peptide derived from the venom of the marine snail Conus generalis. αO-Conotoxin GeXIVA has been shown to selectively inhibit the α9α10 subtype of nicotinic acetylcholine receptors (nAChRs), which are implicated in various physiological and pathological processes, including pain pathways. This specificity makes it a valuable tool for scientific research. Additionally, αO-conotoxin GeXIVA has garnered interest for its potential therapeutic applications, particularly in pain management and cancer treatment.
Specification
| Item | αO-Conotoxin GeXIVA |
|---|
| Catalog | MC2010167254 |
| CAS | 2010167-25-4 |
| Molecular Formula | C139H227N55O41S4 |
| Molecular Weight | 3452.89 |
| Purity | >98% |
| Sequence | Thr-Cys-Arg-Ser-Ser-Gly-Arg-Tyr-Cys-Arg-Ser-Pro-Tyr-Asp-Arg-Arg-Arg-Arg-Tyr-Cys-Arg-Arg-Ile-Thr-Asp-Ala-Cys-Val (Disulfide bridge: Cys2-Cys9, Cys20-Cys27) |
| Sequence Shortening | TCRSSGRYCRSPYDRRRRYCRRITDACV (Disulfide bridge: Cys2-Cys9, Cys20-Cys27) |
| Length (AA) | 28 |
| Peptide Content | 100% |
| Form | Lyophilized powder |
| Source | Synthetic peptide |
| Storage | Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20 °C. Keep away from moisture. |
| Solubility | Soluble in water |
| Storage of Solutions | Store up to 1 week at 4 °C or up to 6 months at -20 °C. |
Therapeutic Applications
- Pain management. αO-Conotoxin GeXIVA achieves analgesia by specifically blocking α9α10 nAChR receptors. It shows promise in treating chronic pain conditions, particularly neuropathic pain. Research into αO-conotoxin GeXIVA explores its potential as a novel analgesic, given its ability to modulate pain without the side effects associated with conventional painkillers.
- Cancer treatment. In addition to its analgesic properties, studies have shown that the αO-conotoxin GeXIVA may play a role in cancer treatment. It may inhibit tumor growth and metastasis, thereby exhibiting anticancer properties.
Choose Alfa Chemistry
Alfa Chemistry is dedicated to maintaining exceptional quality and a relentless focus on innovation. We aim to unlock the vast potential of marine resources by offering a diverse array of high-quality products. We are pleased to provide you with top-grade αO-conotoxin GeXIVA at a competitive price. If you have any inquiries or specific requirements, please do not hesitate to contact us.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
