Calyculin A

Inquiry

Description

Calyculin A is a potent and selective inhibitor of protein phosphatases, particularly protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). Originally derived from the marine sponge Disidea calyx, this bioactive compound has attracted significant interest in biochemical research and pharmacology due to its ability to modulate various cellular processes. Its mechanism of action involves the inhibition of dephosphorylation, which can lead to the enhancement of signal transduction pathways associated with cell growth, differentiation, and apoptosis. Given its role in cellular regulation, calyculin A has been utilized as a tool in studies investigating cancer biology, neurobiology, and other fields, thereby contributing to a deeper understanding of the enzymatic processes underlying numerous physiological and pathological conditions.

Specification

Item	Calyculin A
Catalog	MC101932712
CAS	101932-71-2
Molecular Formula	C₅₀H₈₁N₄O₁₅P
Molecular Weight	1009.17
Purity	>98%
Couple Target	Protein Ser/Thr phosphatases
Couple Type	Inhibitor
Appearance	White to off-white solid
Solubility	Soluble in DMSO, ethanol, methanol, acetone, acetonitrile, chloroform, methylene chloride, and benzene.
Source	Isolated from the Discodermia calyx (marine sponge)
MDL Number	MFCD06795864
SMILES	CC1C(CC2(C(C(C(O2)C(CC(C(C)C(C(C)C=C(C)C(=CC=CC(=CC#N)C)C)O)O)OC)OP(=O)(O)O)(C)C)OC1CC=CC3=COC(=N3)C(C)CCNC(=O)C(C(C(COC)N(C)C)O)O)O
InChi Code	InChI=1S/C50H81N4O15P/c1-29(20-22-51)16-14-17-30(2)32(4)24-33(5)42(57)35(7)38(55)25-41(65-13)45-46(69-70(61,62)63)49(8,9)50(68-45)26-39(56)34(6)40(67-50)19-15-18-36-27-66-48(53-36)31(3)21-23-52-47(60)44(59)43(58)37(28-64-12)54(10)11/h14-18,20,24,27,31,33-35,37-46,55-59H,19,21,23,25-26,28H2,1-13H3,(H,52,60)(H2,61,62,63)/b16-14+,18-15+,29-20-,30-17+,32-24+/t31-,33+,34-,35-,37-,38-,39+,40-,41-,42+,43-,44-,45+,46-,50+/m0/s1
InChi Key	FKAWLXNLHHIHLA-YCBIHMBMSA-N
Stability	Store, as supplied, at -20 °C for up to 1 year. Store solutions at -20 °C for up to 3 months.
Storage Temperature	Store at -20 °C.

Applications

Calyculin A has various applications in scientific research and potential therapeutic contexts. Here are some of its notable applications:

Research in cell signaling. Calyculin A is frequently used to study cell signaling pathways, especially those involving phosphorylation and dephosphorylation processes. By inhibiting phosphatases, researchers can analyze the effects of sustained phosphorylation on cellular functions.
Cell cycle regulation. Calyculin A has been widely utilized in the study of cell cycle regulation due to its ability to inhibit protein phosphatases. By blocking these enzymes, calyculin A induces mitotic arrest in a variety of cell types.
Neuroscience research. Calyculin A has been utilized in neuroscience studies to investigate synaptic plasticity and memory. Its effects on signaling pathways involved in neuronal survival and death are also of interest, particularly in neurodegenerative diseases.

Cancer research. Its ability to modulate protein phosphorylation makes calyculin A a valuable tool in cancer research, where phosphatases are often dysregulated.
Drug development. As a phosphatase inhibitor, calyculin A may be explored for developing drugs that target specific signaling pathways in various diseases, including cancer. Its effects on cell cycle progression and apoptosis provide insight into potential therapeutic strategies.
Pharmacological studies. In addition, calyculin A serves as a crucial pharmacological tool for investigating the functions of protein phosphatases in different diseases. Its inhibitory effects enable scientists to dissect the complex pathways involving these enzymes, thereby enhancing our understanding of their contributions to various pathological conditions.

Choose Alfa Chemistry

At Alfa Chemistry, we are dedicated to maintaining the highest standards of quality while relentlessly pursuing innovative solutions. Harnessing the extensive potential of marine resources allows us to offer a wide array of premium products tailored to meet diverse needs. We are excited to present calyculin A at competitive prices and are fully committed to satisfying your specific requirements. If you have any questions or need further information, please do not hesitate to contact us. We look forward to assisting you.

For Research Use Only. Not for use in diagnostic or therapeutic procedures.