Dinophysistoxin 1

Inquiry

Description

Dinophysistoxin 1 is a marine toxin primarily produced by certain dinoflagellate species, including Dinophysis acuminata and Prorocentrum lima. Known for its potent inhibition of serine/threonine protein phosphatases (PPs), specifically PP1 and PP2A, dinophysistoxin 1 significantly impacts crucial biochemical processes. This toxin belongs to the group of okadaic acid toxins, which are known to cause diarrhetic shellfish poisoning (DSP) in humans. When filter-feeding bivalves such as mussels, clams, oysters, and scallops accumulate these toxins, they pose a substantial health risk to humans consuming contaminated shellfish.

Specification

Item	Dinophysistoxin 1
Catalog	MC81720107
CAS	81720-10-7
Synonyms	DTX 1
Molecular Formula	C₄₅H₇₀O₁₃
Molecular Weight	819.03
Purity	>95%
Solubility	Soluble in DMSO, methanol or ethanol.
Appearance	White powder
Melting Point	134 °C
SMILES	O[C@H](CC[C@@H](C[C@@](C)(O)C(O)=O)O1)[C@@]1(C=C(C)C2)O[C@]2([H])[C@H](C)/C=C/[C@@H]3O[C@@]4(O[C@]([C@@H]5O)([H])[C@@](O[C@@]([C@@H](O)C[C@@H]([C@@]6([H])O[C@]([C@@H]7C)(OCCC7)CC[C@H]6C)C)([H])C5=C)([H])CC4)CC3
InChi Code	InChI=1S/C45H70O13/c1-25-21-35(56-45(23-25)36(47)13-12-32(55-45)24-42(7,51)41(49)50)26(2)10-11-31-15-17-43(54-31)18-16-34-40(57-43)37(48)30(6)39(53-34)33(46)22-28(4)38-27(3)14-19-44(58-38)29(5)9-8-20-52-44/h10-11,23,26-29,31-40,46-48,51H,6,8-9,12-22,24H2,1-5,7H3,(H,49,50)/b11-10+/t26-,27-,28+,29-,31+,32+,33+,34-,35+,36+,37-,38+,39+,40-,42-,43-,44-,45-/m1/s1
InChi Key	CLBIEZBAENPDFY-OOVUYDAUSA-N
Storage Temperature	Store at -20 °C, protect from light.

Research Fields

Toxicological research. Dinophysistoxin 1 is utilized as a model compound to investigate the effects of marine toxins on human health, thanks to its well-defined toxicity profile. This makes it an invaluable resource for researchers aiming to uncover the mechanisms behind diarrhetic shellfish poisoning and to develop effective methods for detecting contamination in seafood.
Pharmacological research. The inhibitory effects of dinophysistoxin 1 on phosphatases are being examined for their potential therapeutic applications. By delving into these inhibitory pathways, researchers aim to discover novel treatments for diseases associated with abnormal phosphorylation states, such as cancer.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.