The marine environment possesses various spectra of species (i.e., animals and plants) that make important contributions to global economic growth. For example, sponges are a potentially active and renewable resource with a wide range of applications in the pharmaceutical field. Cytarabine (Ara-C), isolated from marine sponges by researchers, is the first marine-derived anticancer drug. It has important anti-cancer properties and has been used clinically for decades. In recent years, biomedical researchers have been working to discover drugs using marine resources, especially marine natural products. However, not all marine natural products have properties suitable for development as drugs, and therefore, rigorous druggability analysis is required to identify promising candidates.
Druggability (also known as tractability) is an important concept in drug discovery that influences target identification and may impact the clinical development success rate [1]. Druggability analysis is the process of evaluating the suitability of a molecule to be developed as a drug. It involves a comprehensive assessment of a molecule's physicochemical properties, pharmacokinetics, toxicity, and other parameters that are essential for drug development. Alfa Chemistry is proud to offer our customers druggability analysis of marine natural products to help you make informed decisions during the drug development process.
Our Analysis Projects
Our team of experts utilizes the latest technologies and methods to analyze the druggability of marine natural products. Our analysis projects include, but are not limited to the following.
- Physicochemical Properties
Physicochemical properties such as solubility, stability, and permeability are essential for drug development. Marine natural products have complex structures and unusual physicochemical properties. Therefore, it is necessary to use techniques such as computational modeling, NMR spectroscopy and X-ray crystallography to analyze these properties of marine natural products.
Pharmacokinetics describes how a drug moves into, through and out of the body, tracking its absorption, distribution, metabolism and excretion (or ADME, for short), which together control the concentration of the drug in the body over time [2]. Marine natural products may have different ADME profiles than synthetic drugs, which can affect their bioavailability and efficacy. Therefore, it is necessary to evaluate the ADME properties of marine natural products by in vitro and in vivo tests.
Toxicity is another critical factor in druggability analysis. Marine natural products may have toxic effects on humans and the environment, which can limit their development as drugs. Therefore, toxicity assays are used to evaluate the safety of marine natural products.
Our Advantages
- Advanced technologies and methods
Alfa Chemistry utilizes the latest technologies and methods for druggability analysis of marine natural products, including high-throughput screening, molecular docking, and bioinformatics analysis. Our state-of-the-art equipment and cutting-edge software enable us to quickly and efficiently identify promising compounds for further development.
We work closely with our clients to understand their specific needs and goals, and we tailor our approach accordingly. With our expertise and dedication, we can help our customers accelerate the drug discovery process and bring life-saving treatments to market faster.
We understand the importance of cost-effectiveness in drug discovery, and we strive to ensure that our services are price competitive while providing the highest quality results.
If you have any questions about the service, please feel free to contact us. Alfa Chemistry looks forward to being your project partner.
References
- Raies, A.; et al. DrugnomeAI is an ensemble machine-learning framework for predicting druggability of candidate drug targets. Communications Biology. 2022, 5(1): 1291.
- Mayor S. Pharmacokinetics: optimising safe and effective prescribing. Prescriber. 2017, 28(3): 45-48.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
