Gonyautoxin III

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Description

Gonyautoxin III is a naturally occurring neurotoxin of significant concern due to its ability to disrupt nerve function and its role in paralytic shellfish poisoning. This compound functions as a potent sodium channel blocker by binding with high affinity to site 1 on the α-subunit of voltage-gated sodium channels located in the postsynaptic membrane. This interaction inhibits the flow of ions through the channels, effectively acting as a "stopper" and disrupting the normal electrical conduction. This blockade prevents the transmission of nerve impulses, which can significantly alter neural communication and function.

Specification

Item	Gonyautoxin III
Catalog	MC60537657
CAS	60537-65-7
Synonyms	Gonyautoxin 3; GTX III; GTX3
Molecular Formula	C₁₀H₁₇N₇O₈S
Molecular Weight	395.35
Purity	>95%
Solubility	Soluble in chloroform, dichloromethane, and DMSO
SMILES	C1C(C(C23N1C(=NC(C2N=C(N3)N)COC(=O)N)N)(O)O)OS(=O)(=O)O
InChi Code	InChI=1S/C10H17N7O8S/c11-6-15-5-3(2-24-8(13)18)14-7(12)17-1-4(25-26(21,22)23)10(19,20)9(5,17)16-6/h3-5,19-20H,1-2H2,(H2,12,14)(H2,13,18)(H3,11,15,16)(H,21,22,23)/t3-,4-,5-,9-/m0/s1
InChi Key	ARSXTTJGWGCRRR-LJRZAWCWSA-N
Storage Temperature	Store at 2-8 °C. Protected from air and light.

Applications

Understanding and treating neurological disorders. Studying gonyautoxin III can help researchers understand sodium channel functions in nerve cells, potentially contributing to developments in treating neurological disorders.
Analytical standards. Gonyautoxin III can be used as an analytical standard in the monitoring and quantification of shellfish-toxins in seafood safety testing.
Development of new pain therapeutics. The compound might be used to investigate pain mechanisms and develop new analgesic drugs or nerve blockers due to its effects on nerve transmission.
Environmental monitoring. By monitoring gonyautoxin III levels, researchers can monitor and predict the occurrence of harmful algal blooms.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.