Description
Maitotoxin is an extraordinarily potent toxin produced by the marine dinoflagellate Gambierdiscus toxicus, a single-celled plankton species. This complex molecule features an intricate structure composed of 32 fused rings, resembling large fatty acid chains. Notably, maitotoxin stands out as one of the largest and most intricate non-protein, non-polysaccharide molecules produced by any organism. Its unique ability to facilitate specific intracellular uptake of extracellular calcium ions (Ca2+) has garnered significant attention from researchers, particularly regarding its role in the mechanisms of signal transduction mediated by calcium signaling.
Specification
| Item | Maitotoxin |
|---|
| Catalog | MC59392539 |
| CAS | 59392-53-9 |
| Synonyms | MTX |
| Molecular Formula | C164H256Na2O68S2 |
| Molecular Weight | 3425.86 |
| Purity | >95% |
| Solubility | Soluble in water, aqueous acetonitrile, DMSO, methanol, ethanol, and 1-butanol saturated with water |
| Appearance | Film |
| InChi Key | NWQUHAJRFNRIIU-DVGFTKJRSA-L |
| Storage Temperature | Store at -20 °C. |
Mechanism of Action
Maitotoxin exerts its effects by activating calcium channels in cell membranes, which leads to a significant increase in intracellular calcium levels. This increase in cytosolic calcium levels initiates a cascade of cellular responses, including the secretion of neurotransmitters and hormones, cell depolarization, and the breakdown of phosphoinositides. This dysregulation can result in cellular damage, increased oxidative stress, and ultimately, cell death. Additionally, maitotoxin indirectly activates calcium-dependent proteases, including calpain-1 and calpain-2, which further contribute to the necrotic processes occurring within the affected cells.
Choose Alfa Chemistry
At Alfa Chemistry, we specialize in the production of high-quality marine toxins. Our expertise in marine chemistry ensures that our products meet the highest standards of purity and potency, making them ideal for various applications in research, pharmaceuticals, and biotechnology. We are able to offer maitotoxin at competitive prices. Should you have any specific requirements or inquiries, please do not hesitate to reach out to us. We are enthusiastic about assisting you and look forward to the opportunity to serve your needs effectively.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
