Microcystin-WR

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Description

Microcystin-WR, a variant of microcystin, is a cyclic heptapeptide hepatotoxin produced by certain cyanobacteria, notably those belonging to the Microcystis genus. It is structurally similar to microcystin-LR, differing by the substitution of tryptophan (Trp) for leucine (Leu) at a specific position. Microcystins-WR is recognized for its potent biological activity, particularly its ability to inhibit protein phosphatases. This inhibition can lead to severe toxic effects in a variety of organisms, including humans. Like other microcystins, microcystin-WR has received widespread attention due to its stability and persistence in aquatic environments.

Specification

Item	Microcystin-WR
Catalog	MC138234589
CAS	138234-58-9
Synonym	MC-WR
Molecular Formula	C₅₄H₇₃N₁₁O₁₂
Molecular Weight	1068.22
Purity	>98%
Solubility	Soluble in methanol or DMSO.
Appearance	White powder
Source	Isolated from Microcystis aeruginosa.
SMILES	C[C@H]1[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)C(=C)N(C(=O)CC[C@@H](NC1=O)C(=O)O)C)C)CC2=CNC3=CC=CC=C32)C(=O)O)C)CCCN=C(N)N)/C=C/C(=C/[C@H](C)[C@H](CC4=CC=CC=C4)OC)/C
InChi Code	InChI=1S/C54H73N11O12/c1-29(25-30(2)43(77-8)26-35-15-10-9-11-16-35)20-21-38-31(3)46(67)62-41(52(73)74)22-23-44(66)65(7)34(6)49(70)59-33(5)48(69)63-42(27-36-28-58-39-18-13-12-17-37(36)39)51(72)64-45(53(75)76)32(4)47(68)61-40(50(71)60-38)19-14-24-57-54(55)56/h9-13,15-18,20-21,25,28,30-33,38,40-43,45,58H,6,14,19,22-24,26-27H2,1-5,7-8H3,(H,59,70)(H,60,71)(H,61,68)(H,62,67)(H,63,69)(H,64,72)(H,73,74)(H,75,76)(H4,55,56,57)/b21-20+,29-25+/t30-,31-,32-,33+,38-,40-,41+,42-,43-,45+/m0/s1
InChi Key	UGNOHFGJSOFQHC-ZISXDMAXSA-N
Storage Temperature	Store at -10 °C to -25 °C

Biochemical Properties

Microcystin-WR is known to interact with a variety of enzymes, proteins, and other biomolecules. It has a strong affinity for serine/threonine protein phosphatases (PPs), especially PP1 and PP2A. As a potent inhibitor of this group of enzymes, microcystin-WR plays a significant role in regulating numerous biological pathways. These include essential processes related to cytoskeletal integrity, cell proliferation, stress responses, and DNA repair. The impact of microcystin-WR on these pathways underscores its importance in cellular regulation and highlights the potential consequences of its inhibitory effects on PPs.

Choose Alfa Chemistry

Alfa Chemistry is committed to delivering exceptional quality and continually driving innovation. Our mission is to tap into the immense potential of marine resources, enabling us to offer a diverse range of high-quality products. Specifically, we are pleased to provide top-tier microcystin-WR at competitive prices. Should you have any specific requirements or inquiries, please feel free to reach out to us. We are here to assist you and meet your needs!

For Research Use Only. Not for use in diagnostic or therapeutic procedures.