Description
Okadaic acid sodium is a potent marine toxin derived from Prorocentrum concavum that serves as a specific inhibitor of protein phosphatases (PP). These enzymes play a crucial role in regulating various cellular processes, including signal transduction, cell growth, and apoptosis. This compound exhibits a significantly higher affinity for PP2A, while also inhibiting other phosphatases such as PP1, PP3, PP4, and PP5. Notably, it does not inhibit PP2C. By binding to the active site of these enzymes, okadaic acid sodium prevents the dephosphorylation of various protein substrates, leading to the accumulation of phosphorylated proteins within the cell. It also functions as a tumor promoter. In addition, there is evidence that sodium okadaic acid may have neurotoxic effects, leading to conditions such as diarrhetic shellfish poisoning (DSP). Furthermore, the transport and distribution of okadaic acid sodium within cells and tissues are enhanced by its hydrophobic backbone, facilitating its entry into cells. The sodium salt form of okadaic acid demonstrates improved stability compared to its free acid counterpart when stored in organic solvents, making it a more reliable option for laboratory use and research applications.
Specification
| Item | Okadaic Acid Sodium |
|---|
| Catalog | MC209266808 |
| CAS | 209266-80-8 |
| Molecular Formula | C44H67NaO13 |
| Molecular Weight | 826.98 |
| Purity | >98% |
| Solubility | Soluble in DMSO (1 mg/ml), 100% ethanol, methanol, acetone, ethyl acetate, distilled water, and 50% aqueous acetonitrile (1 mg/ml). |
| Appearance | Faint to clear film |
| Melting Point | 164-166 °C |
| MDL Number | MFCD00210208 |
| SMILES | C[C@@H]1CC[C@]2(CCCCO2)O[C@@H]1[C@@H](C)C[C@@H]([C@@H]3C(=C)[C@H]([C@H]4[C@H](O3)CC[C@]5(O4)CC[C@@H](O5)/C=C/[C@@H](C)[C@@H]6CC(=C[C@@]7(O6)[C@@H](CC[C@H](O7)C[C@](C)(C(=O)[O-])O)O)C)O)O.[Na+] |
| InChi Code | InChI=1S/C44H68O13.Na/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42;/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49);/q;+1/p-1/b10-9+;/t26-,27-,28+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39-,41-,42+,43-,44-;/m1./s1 |
| InChi Key | BYHIFOCTDVNQQT-GHIYGBLASA-M |
| Storage Temperature | -20 °C |
Research Fields
Okadaic acid sodium serves as a critical tool across various scientific fields, particularly in chemistry, biology, medicine, and industry.
- In the realm of chemistry, okadaic acid sodium is instrumental in exploring the mechanisms of protein phosphatases, which are pivotal in numerous biochemical pathways. Researchers utilize okadaic acid sodium to gain insight into the regulatory functions of these enzymes, thereby enhancing our understanding of complex cellular processes.
- In biological research, its application extends to investigating vital cellular processes such as the cell cycle, apoptosis, and signal transduction. By inhibiting protein phosphatases, okadaic acid sodium provides a unique probe for elucidating these mechanisms, revealing intricate details about how cells respond to internal and external signals.
- In medical research, okadaic acid sodium is particularly valuable in studying neurodegenerative diseases, including Alzheimer's disease. It aids researchers in understanding the role of protein phosphatases in tau hyperphosphorylation—a key factor in neurodegeneration. This research is crucial for identifying potential therapeutic strategies and advancing our comprehension of disease pathology.
- In industrial research, okadaic acid sodium is employed in the development of assays and diagnostic tools that necessitate the inhibition of protein phosphatases.
Choose Alfa Chemistry
Alfa Chemistry is dedicated to delivering exceptional quality and continuously pushing the boundaries of innovation. Our mission is to harness the vast potential of marine resources, offering a diverse array of premium products. We take pride in our ability to supply high-quality okadaic acid sodium at competitive prices. Should you have any specific needs or inquiries, please do not hesitate to reach out to us.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
