Description
ω-Conotoxin Bu8 is derived from the cone snail Conus bullatus and consists of 25 amino acid residues and 3 disulfide bonds. It is a potent inhibitor of N-type voltage-gated calcium channels (CaV2.2). It is twice as potent as ω-conotoxin MVIIA, an ω-conotoxin currently used to treat severe chronic pain. ω-Conotoxin Bu8 also reversibly inhibits CaV2.2 with high selectivity. Its selectivity for N-type channels allows for targeted pain relief with potentially fewer side effects compared to conventional analgesics.
Specification
| Item | ω-Conotoxin Bu8 |
|---|
| Catalog | MC052 |
| Molecular Formula | C103H174N42O35S6 |
| Molecular Weight | 2753.13 |
| Purity | >98% |
| Sequence | Cys-Lys-Arg-Lys-Gly-Ser-Ser-Cys-Arg-Arg-Thr-Ser-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Asn-Gly-Lys-Cys-NH2 (Disulfide bridge: Cys1-Cys16, Cys8-Cys20, Cys15-Cys25) |
| Sequence Shortening | CKRKGSSCRRTSYDCCTGSCRNGKC-NH2 (Disulfide bridge: Cys1-Cys16, Cys8-Cys20, Cys15-Cys25) |
| Length (AA) | 25 |
| Peptide Content | 100% |
| Form | Lyophilized powder |
| Source | Synthetic peptide |
| Storage | Product as supplied should be stored at -20 °C. Keep away from moisture. |
| Solubility | Soluble in water |
| Storage of Solutions | Store up to one week at 4 °C or up to six months at -20 °C. |
Mechanism of Action
The mechanism of action of ω-conotoxin Bu8 involves its binding to specific voltage-gated calcium channels, particularly the N-type calcium channels (CaV2.2). By inhibiting these channels, ω-conotoxin Bu8 effectively prevents the influx of calcium ions into neurons, which is crucial for the release of neurotransmitters involved in pain signaling. This blockade not only reduces the transmission of pain signals from peripheral nerves to the central nervous system but also modulates pain pathways, making it a valuable compound for the development of novel analgesic therapies.
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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
