Description
ω-Conotoxin CnVIIA is a specialized peptide known for its ability to block voltage-sensitive calcium channels. This peptide was initially extracted from the venom of the fish-hunting cone snail species, Conus consors. Comprising 27 amino acid residues, ω-conotoxin CnVIIA is uniquely structured with three disulfide bridges. This configuration grants it a highly selective affinity for N-type voltage-sensitive calcium channels. The therapeutic promise of ω-conotoxin CnVIIA lies in its capacity to selectively inhibit mammalian CaV isoforms expressed in ascending pain pathways, particularly CaV2.2, which facilitates the N-type current in sensory neurons. Through this selective inhibition, ω-conotoxin CnVIIA exhibits potent analgesic properties.
Specification
| Item | ω-Conotoxin CnVIIA |
|---|
| Catalog | MC760212360 |
| CAS | 760212-36-0 |
| Molecular Formula | C110H179N39O36S7 |
| Molecular Weight | 2848.29 |
| Purity | >98% |
| Sequence | Cys-Lys-Gly-Lys-Gly-Ala-Hyp-Cys-Thr-Arg-Leu-Met-Tyr-Asp-Cys-Cys-His-Gly-Ser-Cys-Ser-Ser-Ser-Lys-Gly-Arg-Cys-NH2 (Disulfide bridge: Cys1-Cys16, Cys8-Cys20, Cys15-Cys27) |
| Sequence Shortening | CKGKGA-{Hyp}-CTRLMYDCCHGSCSSSKGRC-NH2 (Disulfide bridge: Cys1-Cys16, Cys8-Cys20, Cys15-Cys27) |
| Length (AA) | 27 |
| Peptide Content | 100% |
| Form | Lyophilized powder |
| Source | Synthetic peptide |
| Storage | Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20 °C. Keep away from moisture and light. |
| Solubility | Any aqueous buffer |
| Storage of Solutions | Store up to two weeks at 4 °C or up to three months at -20 °C. |
Mechanism of Action
Due to its ability to inhibit pain pathways, ω-conotoxin CnVIIA has been studied as a potential pain relief treatment, particularly in cases of chronic pain and neuropathic pain. It exhibits significant antinociceptive effects in models of acute and chronic pain without producing the side effects commonly associated with traditional analgesics, highlighting its potential as a pain management therapy.
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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
