Description
ω-Conotoxin FVIA, a neurotoxin originally isolated from Conus fulmen, is a highly selective and powerful reversible blocker of voltage-gated N-type calcium channels (CaV2.2). It is particularly effective in blocking nociception in models of inflammatory pain, as well as alleviating allodynia and hyperalgesia in neuropathic pain models. Research has highlighted that ω-conotoxin FVIA possesses significant analgesic potency and demonstrates a superior reversibility, suggesting its potential for the treatment of refractory pain with fewer side effects. Its unique mechanisms and efficacy position it as a promising candidate for pain management therapies.
Specification
| Item | ω-Conotoxin FVIA |
|---|
| Catalog | MC051 |
| Molecular Formula | C98H164N36O33S6 |
| Molecular Weight | 2566.96 |
| Purity | >99% |
| Sequence | Cys-Lys-Gly-Thr-Gly-Lys-Ser-Cys-Ser-Arg-Ile-Ala-Tyr-Asn-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2 (Disulfide bridge: Cys1-Cys16, Cys8-Cys20, Cys15-Cys25) |
| Sequence Shortening | CKGTGKSCSRIAYNCCTGSCRSGKC-NH2 (Disulfide bridge: Cys1-Cys16, Cys8-Cys20, Cys15-Cys25) |
| Length (AA) | 25 |
| Peptide Content | 100% |
| Form | Lyophilized powder |
| Source | Synthetic peptide |
| Storage | Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20 °C. |
| Solubility | Any aqueous buffer |
| Storage of Solutions | Store up to two weeks at 4 °C or up to three months at -20 °C. |
Choose Alfa Chemistry
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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
