Description
ω-Conotoxin MVIIA, also known as ziconotide, is a highly potent 25-residue, disulfide-bridged peptide derived from the venom of the sea snail, Conus magus. This peptide is a selective N-type voltage-sensitive calcium channel (VSCC) inhibitor with analgesic and neuroprotective properties. It adopts a compact folded structure, featuring a distinctive loop between cysteine residues at positions 8 and 15. This loop contains critical residues essential for effective binding to its target. The primary function of ω-conotoxin MVIIA is to block N-type voltage-gated calcium channels, which play a crucial role in nerve signal transmission, particularly those related to pain. Therefore, it can be used to treat neuropathic pain. Notably, ω-conotoxin MVIIA is 100 to 1,000 times more potent than morphine, making it an exceptionally powerful analgesic. It has proven to be effective in alleviating acute pain for patients who have become resistant to conventional opiate drugs.
Specification
| Item | ω-Conotoxin MVIIA |
|---|
| Catalog | MC107452891 |
| CAS | 107452-89-1 |
| Molecular Formula | C102H172N36O32S7 |
| Molecular Weight | 2639.18 |
| Purity | >97% |
| Sequence | Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2 (Disulfide bridge: Cys1-Cys16, Cys8-Cys20, Cys15-Cys25) |
| Sequence Shortening | CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (Disulfide bridge: Cys1-Cys16, Cys8-Cys20, Cys15-Cys25) |
| Length (AA) | 25 |
| Peptide Content | 100% |
| MDL | MFCD00145036 |
| InChI Key | BPKIMPVREBSLAJ-BSTPJGAOSA-N |
| Form | White lyophilized solid |
| Source | Synthetic peptide |
| Storage | Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20 °C. |
| Solubility | Water and saline buffer |
| Storage of Solutions | Store up to two weeks at 4 °C or up to six months at -20 °C. |
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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
