Description
ω-Conotoxin MVIIC is a potent neurotoxic peptide containing 26 residues with three disulfide bonds, derived from the venom of the sea snail, Conus magus. This particular conotoxin is a member of the ω-conotoxin family, known for targeting voltage-gated calcium channels, specifically the P/Q-type and N-type channels. ω-Conotoxin MVIIC exhibits the ability to block P/Q-type calcium channels with high affinity, while demonstrating a lower affinity for N-type calcium channels. This differential affinity suggests that ω-conotoxin MVIIC serves as a valuable tool for distinguishing the structural variations in the pore-forming regions of N-type and P/Q-type channels. These types of calcium channels play critical roles in the regulation of neurotransmitter release at presynaptic nerve terminals, each contributing uniquely to the functions of the nervous system. Therefore, effectively differentiating between these channels using ω-conotoxin MVIIC is crucial for advancing our understanding of their specific contributions to neural processes.
Specification
| Item | ω-Conotoxin MVIIC |
|---|
| Catalog | MC147794238 |
| CAS | 147794-23-8 |
| Molecular Formula | C106H178N40O32S7 |
| Molecular Weight | 2749.25 |
| Purity | >97% |
| Sequence | Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-NH2 (Disulfide bridge: Cys1-Cys16, Cys8-Cys20, Cys15-Cys26) |
| Sequence Shortening | CKGKGAPCRKTMYDCCSGSCGRRGKC-NH2 (Disulfide bridge: Cys1-Cys16, Cys8-Cys20, Cys15-Cys26) |
| Length (AA) | 26 |
| Peptide Content | 100% |
| MDL | MFCD00214640 |
| InChI Key | FHVUTHWUIUXZBY-BRYRKPJSSA-N |
| Form | White lyophilized solid |
| Source | Synthetic peptide |
| Storage | Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20 °C. |
| Solubility | Water and saline buffer |
| Storage of Solutions | Store up to two weeks at 4 °C or up to three months at -20 °C. |
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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
