Description
μ-Conotoxin BuIIIC is a peptide toxin that was initially extracted from the marine snail Conus Bullatus. The toxin consists of 26 amino acid residues, including six cysteine residues, which contribute to its stability and biological activity. μ-Conotoxin BuIIIC is known for its ability to selectively block voltage-gated Na channels, which play a crucial role in the generation and propagation of electrical signals in nerves and muscles. Its novel structural features, coupled with its strong inhibitory effects on Na channels in skeletal muscle, especially the skeletal muscle subtype Na(v)1.4, make μ-conotoxin BuIIIC an invaluable tool for elucidating the pharmacophore characteristics of Na(v)1.4. This understanding aids in the design of highly selective ligands tailored to target Na(v)1.4 with precision.
Specification
| Item | μ-Conotoxin BuIIIC |
|---|
| Catalog | MC1400096083 |
| CAS | 1400096-08-3 |
| Molecular Formula | C116H189N49O34S6 |
| Molecular Weight | 3006.44 |
| Purity | >98% |
| Sequence | Ile-Val-Asp-Arg-Cys-Cys-Asn-Lys-Gly-Asn-Gly-Lys-Arg-Gly-Cys-Ser-Arg-Trp-Cys-Arg-Asp-His-Ser-Arg-Cys-Cys-NH2 (Disulfide bridge: Cys5-Cys19, Cys6-Cys25, Cys15-Cys26) |
| Sequence Shortening | IVDRCCNKGNGKRGCSRWCRDHSRCC-NH2 (Disulfide bridge: Cys5-Cys19, Cys6-Cys25, Cys15-Cys26) |
| Length (AA) | 26 |
| Peptide Content | 100% |
| Form | Lyophilized powder |
| Source | Synthetic peptide |
| Storage | Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20 °C. |
| Solubility | Any aqueous buffer |
| Storage of Solutions | Up to two weeks at 4 °C or three months at -20 °C. |
Mechanism of Action
μ-Conotoxin BuIIIC has been identified as a potent and irreversible inhibitor targeting the voltage-gated Na channel, specifically the skeletal muscle subtype Na(v)1.4. By blocking these channels, it inhibits the transmission of electrical signals in muscle cells, making μ-conotoxin BuIIIC a subject of interest in the development of novel analgesics.
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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
