Description
μ-Conotoxin GIIIA is a neurotoxic peptide originally derived from the venom of the marine cone snail species Conus geographus. Comprising 22 amino acids, it adopts a distinctive pyramidal structure that is stabilized by three disulfide bonds and features three hydroxyproline residues. This toxin exhibits a strong preference for blocking the skeletal muscle sodium channel subtype Nav1.4, achieved through a complex interaction between the toxin and the channel pore. Notably, several specific residues within the μ-conotoxin GIIIA peptide contribute to its high affinity binding, underscoring the intricate nature of its mechanism of action.
Specification
| Item | µ-Conotoxin GIIIA |
|---|
| Catalog | MC129129653 |
| CAS | 129129-65-3 |
| Molecular Formula | C100H170N38O32S6 |
| Molecular Weight | 2609.08 |
| Purity | >93% |
| Sequence | Arg-Asp-Cys-Cys-Thr-Hyp-Hyp-Lys-Lys-Cys-Lys-Asp-Arg-Gln-Cys-Lys-Hyp-Gln-Arg-Cys-Cys-Ala-NH2 (Disulfide bridge: Cys3-Cys15, Cys4-Cys20, Cys10-Cys21) |
| Sequence Shortening | RDCCT-{Hyp}-{Hyp}-KKCKDRQCK-{Hyp}-QRCCA-NH2 (Disulfide bridge: Cys3-Cys15, Cys4-Cys20, Cys10-Cys21) |
| Length (AA) | 22 |
| Peptide Content | 100% |
| Color | White |
| MDL | MFCD00671421 |
| InChI Key | JXBJHMUQZOSJPJ-HTVVLJMASA-N |
| Form | Lyophilized powder |
| Source | Synthetic peptide |
| Storage | Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20 °C. |
| Solubility | Soluble in DMSO |
| Storage of Solutions | Store up to two weeks at 4 °C or up to three months at -20 °C. |
Therapeutic Potential
Due to its specific action on ion channels, μ-conotoxin GIIIA is of interest in biomedical research and drug development. It can be used as a tool for studying ion channel functionality and may potentially lead to new therapeutic agents, especially for conditions involving pain, epilepsy, and neuromuscular disorders.
Choose Alfa Chemistry
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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
