Description
μ-Conotoxin KIIIA is a 16-residue μ-conotoxin isolated from Conus kinoshitai. It blocks voltage-gated sodium channels (VGSCs) in mammalian neurons, including Nav1.2, Nav1.4, and Nav1.7 subtypes. By targeting these channels, μ-conotoxin KIIIA can effectively inhibit nerve signal transmission, making it a valuable tool for research in neurophysiology and potential therapeutic applications for pain management. Its unique structure and high specificity for certain sodium channel subtypes highlight its significance in scientific studies aimed at understanding ion channel function and developing novel analgesics.
Specification
| Item | µ-Conotoxin KIIIA |
|---|
| Catalog | MC884469674 |
| CAS | 884469-67-4 |
| Molecular Formula | C70H106N28O22S6 |
| Molecular Weight | 1884.16 |
| Purity | >95% |
| Sequence | Cys-Cys-Asn-Cys-Ser-Ser-Lys-Trp-Cys-Arg-Asp-His-Ser-Arg-Cys-Cys-NH2 (Disulfide bonds: Cys1-Cys9, Cys2-Cys15, Cys4-Cys16) |
| Sequence Shortening | CCNCSSKWCRDHSRCC-NH2 (Disulfide bonds: Cys1-Cys9, Cys2-Cys15, Cys4-Cys16) |
| Length (AA) | 16 |
| Peptide Content | 100% |
| Form | Lyophilized powder |
| Source | Synthetic peptide |
| Storage | Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20 °C. |
| Solubility | Any aqueous buffer |
| Storage of Solutions | Store up to two weeks at 4 °C or up to three months at -20 °C. |
Research and Applications
- Neurological research. μ-Conotoxin KIIIA is used as tools to understand sodium channel functioning in neurons, which can be critical for studying various neurological disorders.
- Pain management. μ-Conotoxin KIIIA can specifically target sodium channels involved in pain pathways, has a potent analgesic effect, and can be used in pain research.
- Drug development. μ-Conotoxin KIIIA is being studied for the development of new painkillers for better efficacy and stability.
Choose Alfa Chemistry
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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
