Description
μ-Conotoxin PIIIA is a potent peptide isolated from the venom of the cone snail species Conus purpurascens and is a sodium channel (Nav1.4) blocker. By blocking the Nav1.4 subtype of voltage-gated sodium channels, μ-conotoxin PIIIA provides insights into the functionality and modulation of sodium channels, which are vital for the conduction of electrical signals in nerves and muscles. Notably, μ-conotoxin PIIIA demonstrates a more irreversible blocking effect on amphibian muscle sodium channels than on their mammalian counterparts. Due to its specific interactions with voltage-gated sodium channels, μ-conotoxin PIIIA serves as a useful probe for studying the function of these channels in various tissues. It has been used in research related to pain mechanisms and neuromuscular transmission.
Specification
| Item | µ-Conotoxin PIIIA |
|---|
| Catalog | MC184840208 |
| CAS | 184840-20-8 |
| Molecular Formula | C103H166N40O28S6 |
| Molecular Weight | 2605.06 |
| Purity | >97% |
| Sequence | Pyr-Arg-Leu-Cys-Cys-Gly-Phe-Hyp-Lys-Ser-Cys-Arg-Ser-Arg-Gln-Cys-Lys-Hyp-His-Arg-Cys-Cys-NH2 (Disulfide bridge: Cys4-Cys16, Cys5-Cys21, Cys11-Cys22) |
| Sequence Shortening | {Pyr}-RLCCGF-{Hyp}-KSCRSRQCK-{Hyp}-HRCC-NH2 (Disulfide bridge: Cys4-Cys16, Cys5-Cys21, Cys11-Cys22) |
| Length (AA) | 22 |
| Peptide Content | 100% |
| Form | White lyophilized solid |
| Source | Synthetic peptide |
| Storage | Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20 °C. |
| Solubility | Water and saline buffer |
| Storage of Solutions | Store up to two weeks at 4 °C or up to three months at -20 °C. |
Mechanism of Action
μ-Conotoxin PIIIA inhibits voltage-gated sodium channels, specifically targeting those in muscle tissues, providing a useful tool for synaptic electrophysiology. This action interferes with the normal propagation of action potentials in excitable cells, leading to paralysis or reduced muscle contraction.
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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
