Description
μ-Conotoxin SIIIA is a tetrodotoxin (TTX)-resistant sodium channel blocker belonging to the class of neurotoxic peptides derived from the venom of the marine cone snail species Conus striatus. This small, yet potent toxin is known for its ability to selectively block voltage-gated sodium channels, particularly the Nav1.2 subtype, which plays a crucial role in the generation and propagation of action potentials in neurons. It also blocks the Nav1.4 and Nav1.6 subtypes with submicromolar potency. μ-Conotoxin SIIIA acts primarily by blocking these sodium channels, leading to a reduction in excitability of the affected tissues. This property makes it a useful probe for studying the function of voltage-gated sodium channels. Notably, the unique structure of μ-conotoxin SIIIA, comprising a loop stabilized by disulfide bonds, contributes to its binding affinity and specificity for sodium channels. Currently, the compound is primarily used in the study of neurological diseases, especially neuropathic pain.
Specification
| Item | µ-Conotoxin SIIIA |
|---|
| Catalog | MC877860327 |
| CAS | 877860-32-7 |
| Molecular Formula | C83H123N33O27S6 |
| Molecular Weight | 2207.46 |
| Purity | >98% |
| Sequence | Pyr-Asn-Cys-Cys-Asn-Gly-Gly-Cys-Ser-Ser-Lys-Trp-Cys-Arg-Asp-His-Ala-Arg-Cys-Cys-NH2 (Disulfide bridge: Cys3-Cys13, Cys4-Cys19, Cys8-Cys20) |
| Sequence Shortening | {Pyr}-NCCNGGCSSKWCRDHARCC-NH2 (Disulfide bridge: Cys3-Cys13, Cys4-Cys19, Cys8-Cys20) |
| Length (AA) | 20 |
| Peptide Content | 100% |
| Form | Lyophilized powder |
| Source | Synthetic peptide |
| Storage | Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20 °C. Protect from moisture. |
| Solubility | Soluble in water |
| Storage of Solutions | Store up to 1 week at 4 °C or up to 6 months at -20 °C. |
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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
