Description
μ-Conotoxin Sx IIIA is a bioactive peptide isolated from the venom of the cone snail species Conus striolatus, commonly found in tropical and subtropical marine environments. It belongs to the μ-conotoxin family, which specifically targets and inhibits voltage-gated sodium channels, particularly the Nav1.4 subtype. By binding to these channels, μ-conotoxin Sx IIIA effectively blocks the flow of sodium ions, leading to the disruption of nerve signaling. Its specificity and potency make it of significant interest for scientific research, particularly in the development of novel analgesics and neurobiological tools.
Specification
| Item | µ-Conotoxin Sx IIIA |
|---|
| Catalog | MC1400096005 |
| CAS | 1400096-00-5 |
| Molecular Formula | C86H152N34O26S6 |
| Molecular Weight | 2270.73 |
| Purity | >98% |
| Sequence | Arg-Cys-Cys-Thr-Gly-Lys-Lys-Gly-Ser-Cys-Ser-Gly-Arg-Ala-Cys-Lys-Asn-Leu-Lys-Cys-Cys-Ala-NH2 (Disulfide bridge: Cys2-Cys15, Cys3-Cys20, Cys10-Cys21) |
| Sequence Shortening | RCCTGKKGSCSGRACKNLKCCA-NH2 (Disulfide bridge: Cys2-Cys15, Cys3-Cys20, Cys10-Cys21) |
| Length (AA) | 22 |
| Peptide Content | 100% |
| Form | Lyophilized powder |
| Source | Synthetic peptide |
| Storage | Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20 °C. |
| Solubility | Any aqueous buffer |
| Storage of Solutions | Store up to two weeks at 4 °C or up to three months at -20 °C. |
Research and Applications
The ability of μ-conotoxin Sx IIIA to effectively inhibit voltage-gated sodium channels positions it as a potential candidate for the development of new analgesic drugs, particularly for conditions like neuropathic pain. Beyond its potential therapeutic uses, μ-conotoxin Sx IIIA is often utilized in molecular biology and pharmacological research to study sodium channel function, mechanisms of action, and the interactions between peptides and ion channels.
Choose Alfa Chemistry
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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
