Description
μ-Conotoxin SxIIIC is a 22-amino acid peptide toxin originally isolated from the marine cone snail species Conus striolatus. This fascinating compound is known for its ability to selectively block voltage-gated sodium channels, including subtypes such as Nav1.4, Nav1.3, Nav1.1, Nav1.6 and Nav1.7, which play a crucial role in pain signaling. This blockade disrupts the propagation of action potentials in neurons, showcasing its potential as a neuropharmacological tool. The selectivity and potency of μ-conotoxin SxIIIC make it play an increasingly important role in the study of neurological diseases.
Specification
| Item | µ-Conotoxin SxIIIC |
|---|
| Catalog | MC047 |
| Molecular Formula | C90H142N42O27S6 |
| Molecular Weight | 2436.75 |
| Purity | >98% |
| Sequence | Arg-Gly-Cys-Cys-Asn-Gly-Arg-Gly-Gly-Cys-Ser-Ser-Arg-Trp-Cys-Arg-Asp-His-Ala-Arg-Cys-Cys-NH2 (Disulfide bridge: Cys3-Cys15, Cys4-Cys21, Cys10-Cys22) |
| Sequence Shortening | RGCCNGRGGCSSRWCRDHARCC-NH2 (Disulfide bridge: Cys3-Cys15, Cys4-Cys21, Cys10-Cys22) |
| Length (AA) | 22 |
| Peptide Content | 100% |
| Form | Lyophilized powder |
| Source | Synthetic peptide |
| Storage | Product as supplied should be stored at -20 °C. Keep away from moisture. |
| Solubility | Soluble in water |
| Storage of Solutions | Store up to 1 week at 4 °C or up to 6 months at -20 °C. |
Research and Applications
- Pain management. Due to its ability to inhibit voltage-gated sodium channels, μ-conotoxin SxIIIC is being studied for their potential to treat pain, particularly chronic pain conditions.
- Neurological studies. The specificity of μ-conotoxin SxIIIC for sodium channels makes it a valuable tool for neuroscientific research, helping in the understanding of pain mechanisms and potential treatments.
- Pharmacology and drug design. The unique properties of μ-conotoxin SxIIIC have led to interest in its use as a template for the development of new pharmacological agents that can mimic its action but with improved safety and efficacy.
Choose Alfa Chemistry
Alfa Chemistry is committed to delivering exceptional quality and fostering innovation. We strive to unlock the immense potential of marine resources by offering a wide range of high-quality products. We are excited to provide you with premium µ-conotoxin SxIIIC at a competitive price. If you have any questions or specific requirements, please feel free to reach out to us.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
